The Universal Antidote – Chlorine Dioxide Documentary

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The Universal Antidote – Chlorine Dioxide Documentary

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Open AccessISSN: 1747-0862
Journal of Molecular and GeneticMedicine
Review Article
Volume 15:S1, 2021
Abstract
Introduction:
The aim of this review is to determine the Effectiveness of Oral Chlorine Dioxide in the Treatment of COVID-19.
Methods:
Research on the mechanism of action of chlorine dioxide on viruses, on the oral consumption of water-solubilized ClO
2
and on its toxicity was reviewed; a quasi-experimental investigation was conducted on the use of oral water-soluble chlorine dioxide in the treatment of 20 patients with active COVID-19 infection, compared to a control group of 20 patients not treated with chlorine dioxide.
Results:
To compare the effect in the experimental group versus the control group, a paired test was performed using the Wilcoxon-Mann-Whitney test (
α
: 95%). Within the experimental group, a significant difference was observed in all general symptoms when comparing day 0 to day 07. Some even disappeared after day 7. Those values that did not disappear completely on day 7 did not differ from those on days 14 and 21 (p>0.05). As for headache, it decreased very significantly (p<0.0001) from day 0 with respect to subsequent days. When comparing the experimental group with the control group on the seventh day post manifestation of symptoms, a significant difference was found in the experimental group with respect to the control group for the symptoms Fever (p: 0000), Cough (p: 0.0001), Chills (p: 0.0015) and Dyspnea (p: 0.0047). When performing the visual analogous comparison of pain in the control group and in the experimental group, it was found that in all the items that make up the scale decreased significantly in this group with respect to the Control group. On day 14 post manifestation the difference was greater (p<0.001). When evaluating both groups (Control and Experimental) in the laboratories, a difference was found for the values for the parameters PC Reactive (p: 0.0398) and DH Lactate (0.0422), with higher scores for the experimental group; no difference was found in the rest of the parameters. The results in general (p<0.05) demonstrate the hypothesis that chlorine dioxide is effective in the treatment of COVID-19. It was found that in all the items that make up the scale decreased significantly in this group with respect to the Control group. On day 14 post manifestation the difference was greater (p<0.001).
Discussion:
When evaluating both groups (Control and Experimental) in the laboratories, a difference was found for the values for the parameters PC Reactive (p: 0.0398) and DH Lactate (0.0422), with higher scores for the experimental group; no difference was found in the rest of the parameters. The results in general (p<0.05) demonstrate the hypothesis that chlorine dioxide is effective in the treatment of COVID-19. It was found that in all the items that make up the scale decreased significantly in this group with respect to the Control group. On day 14 post manifestation the difference was greater (p<0.001). When evaluating both groups (Control and Experimental) in the laboratories, a difference was found for the values for the parameters PC Reactive (p: 0.0398) and DH Lactate (0.0422), with higher scores for the experimental group; no difference was found in the rest of the parameters. The results in general (
p
<0.05) demonstrate the hypothesis that chlorine dioxide is effective in the treatment of COVID-19. a difference was found for the values for the parameters PC Reactive (p: 0.0398) and DH Lactate (0.0422), with higher scores for the experimental group; no difference was found in the rest of the parameters. The results in general (
p
<0.05) demonstrate the hypothesis that chlorine dioxide is effective in the treatment of COVID-19. A difference was found for the values for the parameters PC Reactive (p: 0.0398) and DH Lactate (0.0422), with higher scores for the experimental group; no difference was found in the rest of the parameters. The results in general (
p
<0.05) demonstrate the hypothesis that chlorine dioxide is effective in the treatment of COVID-19.
Conclusion:
Chlorine dioxide is effective in the treatment of COVID-19 and the mechanisms of action by which it acts to achieve it are proposed in this work. We recommend doing more research. We recommend conducting double-blind studies and delving into studies of toxicological safety and therapeutic efficacy of chlorine dioxide in pathologies of epidemiological impact in the near future.
Keywords:
SARS-CoV-2 • COVID-19 • Effectiveness • Chlorine Dioxide
Determination of the Effectiveness of Chlorine Dioxide in the Treatment of COVID 19
Insignares-Carrione Eduardo
1
*, Bolano Gómez Blanca
2
, Andrade Yohanny
3
, Callisperis Patricia
4
, Suxo Ana Maria
5
, Arturo Bernardo Ajata San Martín
6
and Camila Ostria Gonzales
7
1
LVWG Global Research Director, Liechtensteiner Verein für Wissenschaft und Gesundheit, Liechtenstein, Switzerland ( https: //orcid.org/0000-0001-9337-0884 )
2
Director of the Research Department, Genesis Foundation, Colombia
3
Specialist in Medical Bioethics, Oncology Palliative Care Specialist, Spain
4
Director, Orthopedic and Traumatology Specialist, South clinic, La Paz, Bolivia, Spain
5
MSc, Training and Research Center - Bolivia Today Association, Epidemiologist, South Clinic, La Paz, Bolivia, Spain
6
Internal Medicine specialist, C Sorata 1146 V Victory, La Paz, Bolivia, Spain
7
La Paz, Bolivia, Spain (linkedin.com/in/camila-ostria-gonzales-96bb0514a)
*Address for Correspondence:
Dr. Eduardo Insignares-Carrione, LVWG Global Research Director, Liechtensteiner Verein für Wissenschaft und Gesundheit, Switzerland-Liechtenstein; E-mail: eduardoinsignarescarrione@gmail.com / eic@lvwg.org
Copyright: ©
2021 Insignares - Carrione, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received
22 February 2021;
Accepted
01 March 2021;
Published
08 March 2021


J Mol Genet Med, Volume 15:S1, 2021Eduardo IC, et al.
Page 2 of 11
The therapeutic action of chlorine dioxide is given by its selectivity for pH. It means that this molecule dissociates and releases oxygen when it comes into contact with another acid. When it reacts, it becomes sodium chloride (common salt) and at the same time releases oxygen, which in turn oxidizes (burns) the pathogens (harmful germs) of acidic pH present, converting them into alkaline oxides (“ashes”). Therefore, when chlorine dioxide dissociates, it releases oxygen into the blood, as do erythrocytes (red blood cells) through the same principle (known as the Bohr Effect), which is to be selective for acidity. Like blood, chlorine dioxide releases oxygen when it encounters acidity, either from lactic acid or from the acidity of the pathogen. ClO
2
is a size-selective antimicrobial agent.Multicellular tissue has the ability to dissipate this charge and is not affected in the same way. Chlorine dioxide, which is the second strongest disinfectant known after ozone, is much more suitable for use therapeutic since it is also capable of penetrating and eliminating biofilm, which ozone does not do. The great advantage of the therapeutic use of chlorine dioxide is the impossibility of a bacterial resistance to ClO
2
. Although ozone is stronger in terms antiseptics, its high oxidative potential of 2.07 and its short half-life of only 15 minutes at 25°C with a pH value of 7.0 make it less effective, for
in vivo
therapeutic applications [11-20].
Chlorine dioxide antiviral efficacy: Mechanism of antiviral action of ClO
2
ClO
2
exhibits antiviral activity through its oxidative chemistry. A virus consists of an outer shell or shell and an inner nucleic acid core. The viral envelope can be composed of proteins, lipid bilayers, and polysaccharides, and the envelope protects the nucleic acid core, in addition to providing selective binding and receptor cell recognition. Altering or modifying the viral envelope or nucleic acid nucleus will disrupt the modes of viral infection.In the case of SARS-CoV-2, the carbohydrate envelope encloses it and protects it even more, which makes it more difficult to attack than other viruses. Approximately 70% of the entire surface of the spike protein is coated with
Introduction
In December 2019, a new respiratory illness emerged in Wuhan, China. The source of this infection was identified as a new coronavirus, related to other coronaviruses that had previously caused outbreaks of Severe Acute Respiratory Syndrome (SARS) between 2002 and 2004 and Middle East Respiratory Syndrome (MERS) in 2012 (National Institutes of Health, 2020). This virus was called "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2) and the disease resulting from infection by this virus was called "COVID-19". On March 11, 2020, the World Health Organization (WHO) declared COVID-19 a pandemic.Coronaviruses are a group of enveloped RNA viruses that can damage multiple organ systems. Like other coronaviruses, the SARS-CoV-2 virus is a spherical particle with glycoprotein spikes on its surface. Coronaviruses enter host cells when a region of the spike, known as the "receptor-binding domain," binds to angiotensin-converting enzyme 2 (hACE2) in human cells. The viral membrane then fuses with the host cell membrane, allowing the viral genome to enter the host cell.Chlorine dioxide (ClO
2
) has been suggested as a potential agent in the fight against COVID-19 and has been proposed three clinical trials to examine the ability of ClO
2
to treat COVID-19. However, this agent is not well known, is not understood and is even demonized in the medical community; we assume that by confusion conceptual with sodium hypochlorite. Therefore, we set out to verify the effectiveness of oral use of the dioxide of chlorine in COVID-19 through this study, reviewing in depth the history of ClO
2
, its safety/toxicity profile and its possible applications in the fight against COVID-19. The objective of this research is to determine if chlorine dioxide is effective in managing COVID-19 [1-65].
Physical and chemical properties of Chlorine Dioxide (ClO
2
)
Chlorine dioxide, ClO
2
, is a gas under standard conditions with a molar mass of 67.45 g/mol. Typically, ClO
2
gas can be synthesized from the reaction between NaClO
2
(sodium chlorite) and C
l2
, NaClO
2
and HOCl, NaClO
2
, and an acid such as HCl or H
3
PO
4
. It is easily soluble in water with a solubility of 3 g/100 mL https: //www.vyphidroasesores.com/.The reactivity of chlorine dioxide is related to its structure and bond. Chlorine dioxide is a bent symmetric triatomic molecule (C2v point group) with a Cl-O bond length of 147.3 picometers and a bond angle of 117.6 degrees (Figure 1A). ClO
2
has an odd number of electrons with 19 valence electrons and therefore, is a paramagnetic radical. Its electronic structure puzzled chemists for a long time because none of the possible structures and Lewis it is very satisfactory for chlorine dioxide [1-10].The molecular orbital theory reveals that a single electron occupies the highest unoccupied molecular orbital, the p* orbital, which makes the molecule a free radical and explains its reactive nature. The two resonance structures of ClO
2
are shown in Figure 1B. The resonance structures of the ClO
2
radical indicate the forms of a double bond between the central Cl atom and an O atom, and a single bond in combination with a 3-electron bond in the other Cl-O bond. The unpaired electron it is shared between the three atoms within the two different resonance structures. Most of the density of a single electron is found in one or another O atom. This unique arrangement provides ClO
2
with a single unpaired electron and two reaction centers (O and Cl) on which to react.When chlorine dioxide dissolves in water, most of it does not hydrolyze: it remains as a dissolved gas in solution. Another part does, and forms both chlorite ion (ClO
2–
) and chlorate ion (ClO
3–
). The solubility of chlorine dioxide in water at sea level and at 25°C is close to 3 g/L (≈ 3000 ppm). Its solubility increases at lower temperatures. Therefore, when its concentration is greater than 3 grams per liter, it is common to store it at temperatures close to 5°C. Dissolved in pure water, in a hermetically closed container, in the absence of light, and at a low temperature, it is quite stable although it slowly decomposes into chlorine and oxygen. Chlorides catalyze its decomposition. In biological systems, ClO
2
can be expected to play an important role as an antiviral/microbial agent through oxidative chemistry.
Figure 1.
(A). Geometry of the ClO2 molecule with group of points (C2v). The bond angle a is 117.6 O and the length of bond d is 147.3 pm. (B). Two resonance structures of ClO2 are illustrated that reveal the unpaired electron, centered on the Oxygen atom, shared between the three atoms.


J Mol Genet Med, Volume 15:S1, 2021Eduardo IC, et al.
Page 3 of 11
glycans; In the case of SARS-CoV-2, sugars are twice as essential. First of all, because they stabilize the spicule in a conformation that allows it to fit with ACE2 receptors on our cells, the process that initiates infection. By removing some glycans from the surface, the spike protein is destabilized and, furthermore, the binding with these receptors is weakened.A line of research is being developed in post-COVID syndrome by one of the authors (B. Bolano), focusing attention on the possibility that ClO
2
acts at the level of inflammasomes or even NETosis as a possible explanation for the improvement in the post COVID-19 syndrome manifested by hundreds of doctors who have reported cases in the world. The relevance and evidence of these findings to the anti-inflammatory mechanism of action of ClO
2
remains unclear at this time.In order to explore the mechanism of action more deeply, we selected published articles (pubmed, google scholar and other search engines) that describe the action of SARS-CoV-2 in cells, in its interaction with hACE2 and, in In particular, we investigated augmented reality videos or simulation videos based on Silicon, for the three-dimensional representation of the places of action, such as the videos in which the spicular protein and the hACE2 receptor are manipulated, among others, with ChimeraX (UCSF) augmented reality software.Similarly, we reviewed the structure of the virus spike and drew on the research of Daniel Wrapp and Jason S. McLellan of the University of Texas. The three-dimensional image of the spicular S glycoprotein of the SARS-CoV-2 betacoronavirus has been seen with electron cryomicroscopy in record time. Thanks to this image with a resolution of 3.5 Å, it is confirmed that this S protein binds to the hACE2 protein of human cells with a higher affinity than that of the SARS-CoV coronavirus. Protein S is the target of the antibodies that immunize us. Its 3D structure allows us to understand why the monoclonal antibodies published against SARS-CoV are not effective against SARS-CoV-2. Based on this information, we did a study with a doctor in molecular biology from the University of Tsukuba in Japan, in which we sought to build the hypothesis of how chlorine dioxide acts on SARS-CoV-2. As a result, we saw that there is an excellent correlation between its structure and its transmission mechanism, as well as the determination of the sites of action of promising substances or drugs in the treatment of COVID-19 and, however, we have not had the expected results for its rapid control with none of the drugs tested. Bioinformatics is a tool that uses biological data to study biological problems on a wide range of scales, such as evolution, structure, the function and regulation of nucleic acids and proteins with the help of computational methods. In our work in Japan, we carry out in silico analysis, which is a comprehensive quantitative approach that not only provides information on the dynamics of intracellular and intramolecular processes, but ultimately allows us to predict biological behavior from molecular interactions. This was done in our work by focusing on conserved domains, structure, function, and biochemical characteristics to understand the mechanism of action of chlorine dioxide on the spike and SARS-CoV-2 RNA, which is a complete quantitative approach that not only provides information on the dynamics of intracellular and intramolecular processes, but ultimately allows prediction of biological behavior from molecular interactions. This was done in our work by focusing on conserved domains, structure, function, and biochemical characteristics to understand the mechanism of action of chlorine dioxide on the spike and SARS-CoV-2 RNA, which is a complete quantitative approach that not only provides information on the dynamics of intracellular and intramolecular processes, but ultimately allows prediction of biological behavior from molecular interactions. This was done in our work by focusing on conserved domains, structure, function, and biochemical characteristics to understand the mechanism of action of chlorine dioxide on the spike and SARS-CoV-2 RNA (Figure 2).This type of analysis not only provides information on RNA replication, but also simulates the dynamics of the interrelation between the spike and the hACE2 receptor. The investigation began with the nucleotide sequence of the viral RNA, the open reading frames (ORF's) were determined, which once analyzed, revealed the oxidation of guanine to 8-oxoguanine. The other bases were not modified. The amino acids oxidized by chlorine dioxide are found in the spike, located in the helices, S1, S2, RBD and hACE2, which could explain the almost immediate effect of clinical improvements achieved by dioxide

onefour1
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Re: The Universal Antidote – Chlorine Dioxide Documentary

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https://theuniversalantidote.com/

Excellent Video!!! People should really be familiar with Chlorine Dioxide!

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truefreedom
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Re: The Universal Antidote – Chlorine Dioxide Documentary

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THE KING said the vaccine was the only answer!!!!

onefour1
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Re: The Universal Antidote – Chlorine Dioxide Documentary

Post by onefour1 »

Dethrone the KING! You can purchase Chlorine Dioxide products at:

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